March D. Ard

March D. Ard

PROFESSOR EMERITUS

Department:
SOM-Advanced Biomedical Education

Education

University of Connecticut, PhD, Anatomy & Cell Biology1982
University of North Carolina, BA, Psychology1972
Washington University, postdoc with D.I. Gottlieb
Washington University, postdoc with R.P. Bunge

Current Positions

Director, School of Medicine, Department of Anatomy2006 - Present
Associate Professor, School of , Department of Anatomy1994 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Adjunct Instructor, Hinds Community College Biology Department, School of Medicine, Department of Biology Department2007 - 2008
Adunct Instructor, Mississippi College Biology Department, School of Medicine, Department of Biology Department2006 - 2006
Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Anatomy1988 - 1994

Publications

Journal Article

Chen, S., Averett, N.T., Manelli, A., LaDu, M.J., May, W., and Ard, M.D. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. Journal of Alzheimer's Disease 7:25-352005
D'Andrea, M.R., Cole, G.M., and Ard, M.D. A review of the microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol. Aging 25:675-6832004
Cole, G.M. and Ard, M.D. Influence of lipoproteins on microglial degradation of Alzheimer’s amyloid beta-protein. Microscopy Research and Technique 50(4):316-3242000
Sundaram, N., Pahwa, A.K., Ard, M.D., Lin, N., Perkins, E., and Bowles, A.P., Jr. The differential effect of selenium on human brain tumor cells and normal fibroblasts. J. Neuro-Oncology 46: 125-1332000
Cole, G.M., Beech, W., Frautschy, S., Sigel, J., Glasgow, C., and Ard, M.D. Lipoprotein effects on A accumulation and degradation by microglia in vitro. J. Neurosci. Res. 57: 504-5201999
Mohan, P.F. and Ard, M.D. Induction of microglial nitric oxide synthesis by very low density lipoprotein. Glia 17: 259-2621996
Ard, M.D., Cole, G.M., Mehrle, A.P., Wei, J. and Fratkin, J.D. Scavenging of Alzheimer's amyloid -protein by microglia in culture. J. Neurosci. Res. 43: 190-202.1996
Hutchins, J.B. and Ard, M.D. Expression of platelet-derived growth factor and its receptor in rat neuronal and astroglial cultures. Molecular and Cellular Neurosciences 4:250-2581993
Ard, M.D., Schachner, M., Rapp, J. and Faissner, A. Growth and degeneration of axons on astrocyte surfaces: effects on extracellular matrix and on later axonal growth. Glia 9:248-259.1993
Hunter, D.D., Llinas, R., Ard, M., Merlie, J.P. and Sanes, J.R. Expression of S-laminin and laminin in the developing rat central nervous system. J. Comp. Neurol. 323:238-2511992
Ard, M.D. and Faissner, A. Components of astrocytic extracellular matrix are regulated by contact with axons. Ann. N. Y. Acad. Sci. 633:566-5691991
Ard, M.D., Bunge, M.B., Wood, P.M., Schachner, M. and Bunge, R.P. Retinal neurite growth on astrocytes is not modified by extracellular matrix, anti-L1 antibody, or oligodendrocytes. Glia. 4: 70-821991
Johnson, M.I., Higgins, D. and Ard, M.D. Astrocytes induce dendritic development in cultured sympathetic neurons. Dev. Brain. Res. 47: 289-2921989
Ard, M.D. and Bunge, R.P. Changes in astrocyte extracellular matrix with differentiation and after contact with neurites. Ann. N. Y. Acad. Sci. 540: 420-4221989
Rosen, C.L., Bunge, R.P., Ard, M.D. and Wood, P.M. Type 1 astrocytes inhibit myelination by adult rat oligodendrocytes in vitro. J. Neurosci. 9: 3371-33791989
Bunge, R.P., Kleitman, N., Ard, M.D. and Duncan, I.D. Culture preparations of neuroglia cells useful for studies of myelin repair and axonal regeneration in the central nervous system. In: Proceedings of the Schmitt Symposium: Transplantation into the Mammalian CNS, D.M. Gash, J.R. Sladek, eds., Progress in Brain Research, Elsevier, Amsterdam1988
Ard, M.D. and Bunge, R.P. Heparan sulfate proteoglycan and laminin immunoreactivity on astrocytes: Relationship to differentiation and to neurite growth. J. Neurosci. 8: 2844-28581988
Bunge, R.P., Eldridge, C.F., Ard, M.D. and Kleitman, N. Schwann cell contact as a factor in neuronal trophic support and the promotion of neurite growth. In: Neurobiology of Amino Acids, Peptides and Trophic Factors, (J. Ferrendelli, R. Collins and E. Johnson, eds.) Kluwer Academic, Boston, pp. 115-1261988
Ard, M.D., Bunge, R.P. and Bunge, M.B. A comparison of the Schwann cell surface and Schwann cell extracellular matrix as promoters of neurite growth. J. Neurocytol. 16: 539-5551987
Bunge, M.B., Johnson, M.I., Ard, M.D. and Kleitman, N. Factors influencing the growth of regenerating nerve fibers in culture. In: Proceedings of the International Symposium on Neural Regeneration, (Prog. in Brain Res. Vol. 71) Elsevier, pp. 61-741987
Ard, M.D., Goldstein, M.N., Nash, D.R. and Gottlieb, D.I. NMB: A human neuroblastoma cell line with specific opiate binding sites. Biochem. Biophys. Res. Comm. 133: 60-66.1985
Ard, M.D., Morest, D.K. and Hauger, S.H. Trophic interactions between the stato-acoustic ganglion of the chick embryo and its synaptic targets in culture. Neuroscience 16: 151-1701985
Ard, M.D. and Morest, D.K. Cell death during development of the auditory and vestibular ganglia of the chick. Int. J. Dev. Neurosci. 2: 535-5471984
Ard, M.D. Trophic interactions between the stato-acoustic ganglion of the chick embryo and its synaptic targets. Dissertation, Univ. of Connecticut1982
Tuttle, J.B., Suszkiw, J.B. and Ard, M. Long-term survival and development of dissociated parasympathetic neurons in culture. Brain Res. 183: 161-180.1980
Cheek, M.D. (Ard), Rustioni, A. and Trevino, D.L Dorsal column nuclei projections to the cerebellar cortex in cats as revealed by the use of the retrograde transport of horseradish peroxidase. J. Comp. Neurol. 164: 31-461975

Book Chapter

Frautschy, S.A., Cole, G.M., and Ard, M.D. Beta amyloid protein clearance and microglial activation In Microglia in the Regenerating and Degenerating CNS, ed. by W. J. Streit (Springer-Verlag, New York).2001

Letter to the Editor

Ard, M.D. Role of electrical activity in the formation of topographic maps. TINS 8: 521-5221985

Professional Membership and Service

Human Anatomy & Physiology Society, Member2008 - Present
Proceedings of the National Academy of Sciences, Reviewer, Ad Hoc Reviewer2007
Alzheimer's Association, Reviewer, Ad Hoc Reviewer2003 - 2008
Journal of Alzheimer's Disease, Reviewer, Ad Hoc Reviewer2003 - 2008
American Association of Anatomists, Member1994 - Present
Sigma Xi, Member1994 - Present
Alzheimer's Association, Reviewer, Grant Proposal
Archives of biochemistry and biophysics, Reviewer, Journal Article, Archives of biolchemistry and biophysics
Biotechnic and Histochemistry, Reviewer, Journal Article, Biotechnic and Histochemistry
Glia, Reviewer, Journal Article, Glia
National Institutes of Health, Reviewer, Grant Proposal
National Science Foundation, Reviewer, Grant Proposal
Neurobiology of Aging, Reviewer, Journal Article, Neurobiology of Aging
Neuroscience Letters, Reviewer, Journal Article, Neuroscience Letters
New Zealand Neurological Foundation, Reviewer, Grant Proposal
Paralyzed Veterans of America Spinal Cord REsearch Foundation, Reviewer, Grant Proposal
The Anatomical Record, Reviewer, Journal Article, The Anatomical Record
The Journal of Neuroscience, Reviewer, Journal Article, The Journal of Neuroscience

Committee Service

School Of Graduate Studies - Curriculum Committee, Member2008 - Present
Medical Center - Institutional Assessment, Member2007 - 2009
School Of Graduate Studies - Graduate Council, Member2006 - Present
Animal Care and Use, Member1995 - 1996
School Of Medicine - Admissions, Member1993 - 2005

Community Service

Public lectures about neurological disease for Mississippi Chapter of Alzheimer’s Association,Mississippi Chapter of National Multiple Sclerosis Society, church, and nursing home, speaker1993 - 2004

Other Service

Director of the Graduate Program in Anatomy, Director of the Graduate Program in Anatomy07/2006 - Present

Teaching Experience

722, Graduate, Small Group, Course Director, Advanced Topics in AnatomyFall 2010
713, Graduate, Lecture, Course Presenter, Histology and Cell BiologyFall 2010
613, Medicine, Lecture, Course Presenter, Medical Histology and Cell BiologyFall 2010
722, Graduate, Small Group, Course Director, Advanced Topics in AnatomySpring 2010
713, Graduate, Lecture, Course Presenter, Histology and Cell BiologySpring 2010
613, Medicine, Lecture, Course Presenter, Medical Histology and Cell BiologySpring 2010
722, Graduate, Small Group, Course Director, Advanced Topics in AnatomyFall 2009
713, Graduate, Lecture, Course Presenter, Histology and Cell BiologyFall 2009
613, Medicine, Lecture, Course Presenter, Histology and Cell Biology for first-year medical StudentsFall 2009
713, Graduate, Lecture, Course Presenter, Histology & Cell BiologySpring 2009
613, Medicine, Lecture, Course Presenter, Histology and Cell BiologySpring 2009

Directed Student Learning

Dissertation Committee Member, Advised: Eddie Perkins2006 - 2006
Dissertation Committee Member, Advised: Yan Pan2003 - 2003
Dissertation Committee Member, Advised: Min Pan1999 - 1999
Dissertation Committee Member, Advised: Xiaorong Zhang1996 - 1996
Doctoral Advisory Committee Chair, The effects of apolipoprotein E and beta amyloid protein on the secretion of inflammatory mediators in adult rat microglia
Advised: Shuang Chen
Master's Thesis Committee Chair, Clearance of Alzheimer's amyloid beta-protein by microglia in culture
Advised: Jinrong Wei

Fellows supervised

Anatomy, Training Faculty, 1 fellows supervised, Educational Committee for Foreign Medical Graduates