Nicole M. Anderson, PhD

Nicole M. Anderson, PhD

Assistant Professor

Department:
SOM-Cell and Molecular Biology

Email:
nanderson1@umc.edu

Work Phone:
(601) 984-2772

Education

University of Toronto, PhD, Genetics/Hematopoietic Disease2011
University of Waterloo, BS, Biology

Current Positions

Assistant Professor, School of Medicine11/2022 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Publications

Letter

Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H, CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica, 2017 Jan;102(1):e17-e212017
Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H, BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia, 2014 May;28(5):1145-82014

Journal Article

Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC, Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer. Nature cancer, 2024 Jan;5(1):131-1462024
Missiaen R, Anderson NM, Kim LC, Nance B, Burrows M, Skuli N, Carens M, Riscal R, Steensels A, Li F, Simon MC, GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell metabolism, 2022 Aug 2;34(8):1151-1167.e72022
Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H, Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer research, 2021 Sep 1;81(17):4417-44302021
Anderson NM, Simon MC, The tumor microenvironment. Current biology : CB, 2020 Aug 17;30(16):R921-R9252020
Anderson NM, Simon MC, BACH1 Orchestrates Lung Cancer Metastasis. Cell, 2019 Jul 11;178(2):265-2672019
Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H, UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia, 2018 Nov;32(11):2339-23512018
Anderson NM, Mucka P, Kern JG, Feng H, The emerging role and targetability of the TCA cycle in cancer metabolism. Protein & cell, 2018 Feb;9(2):216-2372018
Anderson NM, Li D, Peng HL, Laroche FJ, Mansour MR, Gjini E, Aioub M, Helman DJ, Roderick JE, Cheng T, Harrold I, Samaha Y, Meng L, Amsterdam A, Neuberg DS, Denton TT, Sanda T, Kelliher MA, Singh A, Look AT, Feng H, The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia, 2016 Jun;30(6):1365-742016
Harrold I, Carbonneau S, Moore BM, Nguyen G, Anderson NM, Saini AS, Kanki JP, Jette CA, Feng H, Efficient transgenesis mediated by pigmentation rescue in zebrafish. BioTechniques, 2016 Jan;60(1):13-202016
Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N, Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis, 2015 Oct;18(4):449-622015
Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL, Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Experimental hematology, 2012 Jan;40(1):48-602012
Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL, A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Experimental hematology, 2011 Mar;39(3):305-20, 320.e1-22011
Wang CH, Anderson N, Li SH, Szmitko PE, Cherng WJ, Fedak PW, Fazel S, Li RK, Yau TM, Weisel RD, Stanford WL, Verma S, Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circulation research, 2006 Sep 15;99(6):617-252006
Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J, A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (Cambridge, England), 2005 Oct;132(19):4375-862005
Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL, Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PloS one, 2013;8(9):e75472

Presentations

National and International Invited Seminars/Lectures, A MYCN-Driven Zebrafish Model of High-Risk Neuroblastoma Exhibits Early Metastatic Dissemination, ZDM17, Lisbon Portugal10/2024
State/Local Invited Seminars/Lectures, Utilizing Zebrafish to Model Metastatic Dissemination in High-Risk Neuroblastoma., CRRC, Jackson MS03/2024
State/Local Invited Seminars/Lectures, Defining Mechanisms of Dissemination and Treatment Resistance in Neuroblastoma, Neuroscience Seminar Series, Jackson MS02/2024
Regional Invited Seminars/Lectures, DLST, Tumor Aggression, and Bioenergetics in High-Risk Neuroblastoma., Tristate Metabolism Meeting, Princeton NJ10/2021
National and International Invited Seminars/Lectures, Metabolic Enzyme DLST Drives Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma, Cold Spring Harbor Laboratory Virtual Meeting, Virtual10/2021

Committee Service

ZDMS - Early Career Investigator Committee, Co-Chair2023 - Present
CMB - Graduate Commitee, Member2023 - Present