Nicole M. Anderson, PhD
Assistant Professor
Department:
SOM-Cell and Molecular Biology
Email:
nanderson1@umc.edu
Work Phone:
(601) 984-2772
Education
| University of Toronto, PhD, Genetics/Hematopoietic Disease | 2011 |
| University of Waterloo, BS, Biology |
Current Positions
| Assistant Professor, School of Medicine | 11/2022 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Publications
Letter | |
| Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H, CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica, 2017 Jan;102(1):e17-e21 | 2017 |
| Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H, BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia, 2014 May;28(5):1145-8 | 2014 |
Journal Article | |
| Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC, Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer. Nature cancer, 2024 Jan;5(1):131-146 | 2024 |
| Missiaen R, Anderson NM, Kim LC, Nance B, Burrows M, Skuli N, Carens M, Riscal R, Steensels A, Li F, Simon MC, GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell metabolism, 2022 Aug 2;34(8):1151-1167.e7 | 2022 |
| Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H, Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer research, 2021 Sep 1;81(17):4417-4430 | 2021 |
| Anderson NM, Simon MC, The tumor microenvironment. Current biology : CB, 2020 Aug 17;30(16):R921-R925 | 2020 |
| Anderson NM, Simon MC, BACH1 Orchestrates Lung Cancer Metastasis. Cell, 2019 Jul 11;178(2):265-267 | 2019 |
| Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H, UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia, 2018 Nov;32(11):2339-2351 | 2018 |
| Anderson NM, Mucka P, Kern JG, Feng H, The emerging role and targetability of the TCA cycle in cancer metabolism. Protein & cell, 2018 Feb;9(2):216-237 | 2018 |
| Anderson NM, Li D, Peng HL, Laroche FJ, Mansour MR, Gjini E, Aioub M, Helman DJ, Roderick JE, Cheng T, Harrold I, Samaha Y, Meng L, Amsterdam A, Neuberg DS, Denton TT, Sanda T, Kelliher MA, Singh A, Look AT, Feng H, The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia, 2016 Jun;30(6):1365-74 | 2016 |
| Harrold I, Carbonneau S, Moore BM, Nguyen G, Anderson NM, Saini AS, Kanki JP, Jette CA, Feng H, Efficient transgenesis mediated by pigmentation rescue in zebrafish. BioTechniques, 2016 Jan;60(1):13-20 | 2016 |
| Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N, Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis, 2015 Oct;18(4):449-62 | 2015 |
| Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL, Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Experimental hematology, 2012 Jan;40(1):48-60 | 2012 |
| Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL, A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Experimental hematology, 2011 Mar;39(3):305-20, 320.e1-2 | 2011 |
| Wang CH, Anderson N, Li SH, Szmitko PE, Cherng WJ, Fedak PW, Fazel S, Li RK, Yau TM, Weisel RD, Stanford WL, Verma S, Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circulation research, 2006 Sep 15;99(6):617-25 | 2006 |
| Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J, A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (Cambridge, England), 2005 Oct;132(19):4375-86 | 2005 |
| Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL, Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PloS one, 2013;8(9):e75472 | |
Presentations
| State/Local Invited Seminars/Lectures, Employing Zebrafish Models of Cancer to Solve Enigmas in Oncogenesis, Department of Biology, Oxford MS | 10/2024 |
| Platform Presentations, A MYCN-Driven Zebrafish Model of High-Risk Neuroblastoma Exhibits Early Metastatic Dissemination, ZDM17, Lisbon Portugal | 10/2024 |
| Poster Presentation, A Zebrafish Model of High-Risk Neuroblastoma Exhibits Multifocal Primary Disease., American Association of Cancer Research – Advances in Pediatric Cancer Research, Toronto Canada | 09/2024 |
| State/Local Invited Seminars/Lectures, Utilizing Zebrafish to Model Metastatic Dissemination in High-Risk Neuroblastoma., CRRC, Jackson MS | 03/2024 |
| State/Local Invited Seminars/Lectures, Defining Mechanisms of Dissemination and Treatment Resistance in Neuroblastoma, Neuroscience Seminar Series, Jackson MS | 02/2024 |
| Poster Presentation, Understanding Early Tumor Development of a MYCN-Driven Zebrafish Model of Neuroblastoma., Zebrafish Disease Models 16 Conference, Durham North Carolina | 10/2023 |
| Regional Invited Seminars/Lectures, DLST, Tumor Aggression, and Bioenergetics in High-Risk Neuroblastoma., Tristate Metabolism Meeting, Princeton NJ | 10/2021 |
| National and International Invited Seminars/Lectures, Metabolic Enzyme DLST Drives Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma, Cold Spring Harbor Laboratory Virtual Meeting, Virtual | 10/2021 |
| Poster Presentation, Metabolic Enzyme DLST Drives Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma, Zebrafish Disease Models 14 Conference, Virtual | 10/2021 |
| National and International Invited Seminars/Lectures, DLST, Tumor Aggression, and Bioenergetics in High-Risk Neuroblastoma., Zebrafish Disease Models Society Gone Viral Seminar Series, virtual | 05/2020 |
| Poster Presentation, Defining the role of DLST in MYCN-driven neuroblastoma., Biomedical Postdoctoral Research Symposium, Philadelphia PA | 10/2019 |
| Poster Presentation, Defining the role of DLST in MYCN-driven neuroblastoma., ACR Cancer Metabolism Meeting, New York, NY | 09/2018 |
| Poster Presentation, Defining the role of DLST in MYCN-driven neuroblastoma, iomedical Postdoctoral Research Symposium, Philadelphia PA | 10/2017 |
| Poster Presentation, Defining the role of DLST in MYCN-driven neuroblastoma, Zebrafish Disease Models 10 Conference, San Deigo CA | 10/2017 |
| State/Local Invited Seminars/Lectures, Defining the Role of the TCA Cycle Enzyme, DLST, in MYCN-Driven Neuroblastoma., Biomedical Postdoctoral Research Symposium, Philadelphia | 01/2017 |
| Platform Presentations, Defining the Role of DLST in MYCN-Driven Neuroblastoma, Zebrafish Disease Models 10 Conference, San Deigo CA USA | 01/2017 |
| State/Local Invited Seminars/Lectures, The TCA cycle transferase DLST is important for MYC-mediated tumorigenesis, Department of Cancer Biology UPenn, New Jersey | 01/2017 |
| Poster Presentation, The TCA Cycle Transferase DLST is Important for MYC-mediated Leukemogenesis, American Association of Cancer Research 2016, New Orleans LA USA | 04/2016 |
| Poster Presentation, The TCA Cycle Transferase DLST is Important for MYC-mediated Leukemogenesis, Keystone Symposia: New Frontiers in Understanding Tumor Metabolism, Banff, Alberta CA | 02/2016 |
| Poster Presentation, Understanding the Role of DLST in MYCN-driven Neuroblastoma., Zebrafish Disease Models Conference 2015., Boston MA USA | 08/2015 |
| Poster Presentation, A Genetic Screen in Zebrafish Identifies DLST as an Important Factor in Myc-Driven T-ALL Transformation and a Potential Therapeutic Target in T-AL, American Society of Hematology Annual Meeting, New Orleans | 12/2013 |
| Platform Presentations, A Novel Regulator in Terminal Megakaryocyte Differentiation Identified by ENU Mutagenesis., International Mammalian Genome Conference, Prague, Czech Republic | 10/2008 |
| Poster Presentation, A Novel Regulator in Terminal Megakaryocyte Differentiation Identified by ENU Mutagenesis., nternational Mammalian Genome Conference, Prague Czech Republic | 10/2008 |
| Poster Presentation, Understanding the Role of Connexin 43 and Gap Junctions in the Bone Marrow Niche, nternational Society of Stem Cell Research Annual Meeting, Philadelphia | 05/2008 |
| Poster Presentation, Novel ENU-induced Mutation in Ankyrin 1 Provides New Insights into Hereditary Spherocytosis, nternational Society for Experimental Research Annual Meeting, Hamburg, Germany | 10/2007 |
| Platform Presentations, Evaluating the Success of a Pharmacologically Sensitized screen to Detect Defects in Hematopoiesis., Mount Sinai Hospital, Toronto Ontario CA | 04/2007 |
| Poster Presentation, The Role of Gja1 Gap Junctions in the Bone Marrow Niche, American Society for Hematology Annual Meeting, Orlando Fl USA | 12/2006 |
| Platform Presentations, ENU mutant mouse model of Oculodentodigital dysplasia is exploited to understand the role of connexin 43 in blood and bone development., International Mammalian Genome Conference, Charleston NC USA | 10/2006 |
| Poster Presentation, An ENU mutant mouse model of Oculodentodigital dysplasia is exploited to understand the role of connexin 43 in blood and bone development., nternational Mammalian Genome Conference 2006, Strasburg France | 10/2006 |
| Poster Presentation, Development and implementation of a viable, pharmacologically sensitized ENU screen to identify hematopoietic mutants in the mouse., nternational Mammalian Genome Conference 2005, Strasburg FA | 10/2005 |
| Poster Presentation, Induction of transient cytopenia to detect hematopoietic defects in the mouse., reat Lakes Mammalian Development Meeting, Toronto On. CA | 05/2005 |
| Platform Presentations, Induction of transient anemia to detect hematopoietic defects in the mouse., International Mammalian Genome Conference, Strasbourg, France | 10/2004 |
| Poster Presentation, Induction of transient anemia to detect hematopoietic defects in the mouse., Great Lakes Mammalian Development Meeting, Toronto CA | 05/2004 |
Committee Service
| ZDMS - Early Career Investigator Committee, Co-Chair | 2023 - Present |
| CMB - Graduate Commitee, Member | 2023 - Present |