Lorena M. Amaral, PhD
Associate Professor
Department:
SOM-Pharmacology/Toxicology
Email:
lmamaral@umc.edu
Work Phone:
(601) 815-1401
Biography
Dr. Lorena M. Amaral is an Associate Professor in the Department of Pharmacology and Toxicology at the University of Mississippi Medical Center.
Dr. Amaral is member of American Heart Association (AHA), American Physiological Society (APS), American Society for Pharmacology and Experimental Therapeutics (ASPET), Society for Reproductive Investigation (SRI) and Society for Maternal Fetal Medicine (SMFM). She has served as ad-hoc member on grant review panels for the American Heart Association. She has also served as peer-reviewer for over 10 international scientific journal such as BMC Pregnancy and Childbirth, Circulation, Heliyon, PLOS, Hypertension, among others. Also, she has served as guest editor for international scientific journal. In addition, she has provided service as a scientific judge in several local science fairs.
Dr. Amaral has authored over 65 peer-reviewed papers on diverse topics of hypertensive pregnancy disorder research and sent over 70 abstracts to national/international scientific meetings. Her research has been funded by agencies from Brazil and United States. She has received several awards such as Career Development Award (CDA-AHA), Caroline tum Suden/Hellebrandt Professional Opportunity Award (APS) and the most outstanding basic science oral presentation in relation to the study of hypertension in pregnancy from ISSHP.
She serves in multiple leadership capacities, including Associate Program Director and MFM track, Master in Clinical Science Investigation, UMMC; GWIMS mentoring chair and secretary; Pharmacology Graduate Admission Committee-Member, Pharmacology Department; SOM Curriculum Foundation Science-Member; SOM- Curriculum Program Evaluation Subcommittee-Member, UMMC; PhD and Master advisory committee, UMMC; Master in Clinical Science admission committee-member. Over the past few years, she has mentored graduate students, M.D fellows and served as PI or Co-investigator on a number of clinical and basic science research grants that have investigated preeclampsia and gestational hypertension.
Dr. Amaral’s research is focused on translational studies investigating novel therapeutic targets for hypertensive disorders of pregnancy.
Education
| University of Mississippi Medical Center, Postdoctoral Research Fellow, Pharmacology | 2017 |
| Universirty of Sao Paulo, PhD, Pharmacology | 2012 |
| University of Sao Paulo, MS, Pharmacology | 2010 |
| Federal University of Juiz de Fora, PharmD, Pharmacist | 2008 |
Current Positions
| Associate Professor, School of Medicine | 07/2024 - Present |
| Clinical Investigation Assistant Program Director, School of Graduate School in the Health Sciences | 07/2023 - Present |
| Track Director Maternal Fetal Medicine, School of Graduate School in the Health Sciences | 07/2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Medicine | 07/2021 - 06/2024 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 04/2019 - 06/2021 |
| Instructor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 09/2017 - 03/2019 |
| Scientist, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 08/2016 - 09/2017 |
| Postdoctoral, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 01/2013 - 08/2016 |
Sponsored Program Funding
| Extramural, Novel therapy to treat vascular dysfunction, renal dysfunction, and hypertension in females, National Institutes of Health | 07/2025 - 06/2030 |
| Extramural, Causes of Sex Differences in male and female offspring born from inflammation mediated hypertensive pregnancy, National Institutes of Health | 05/2025 - 04/2030 |
| Extramural, Novel Pharmacological Treatment for Preeclampsia, National Institutes of Health | 09/2023 - 08/2024 |
| Extramural, Novel therapy for preeclampsia, National Institutes of Health | 09/2022 - 08/2023 |
| Extramural, Progesterone as a treatment option for superimposed PE, National Institutes of Health/National Institute of General Medical Sciences | 08/2022 - 07/2027 |
| Extramural, Progesterone and PIBF: new insights into treatment options for preeclampsia, Mississippi Center for Clinical and Translational Research (MCCTR) | 12/2020 - 08/2022 |
| Extramural, Benefits of progesterone: missing in action during preeclampsia, American Heart Association | 04/2019 - 03/2022 |
| Extramural, Anti-inflammatory effects of progesterone, Mississippi Center of Excellence in Perinatal Research (CEPR) Pilot Project on grant 5P20GM121334-02 | 06/2018 - 05/2019 |
| Extramural, AMAG Pharmaceuticals. Title: “17-Hydroxyprogesterone Caproate Supplementation: A Novel Therapeutic for the Management of Preeclampsia?”, AMAG | 11/2016 - 12/2018 |
| Extramural, Effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia, São Paulo Research Foundation (FAPESP), Sao Paulo State, Brazil | 01/2011 - 11/2012 |
| Extramural, Effects of genetics polymorphisms of iNOS on the susceptibility in hypertensive disorders of pregnancy, National Council for Scientific and Technological Development (CNPq) | 01/2009 - 12/2010 |
Publications
Journal Article | |
| Alexis Meadors, Kyleigh Comley, Jesse N. Cottrell,Tarek Ibhahim, Mark W. Cunningham Jr., Lorena M. Amaral Progesterone-induced blocking factor blockade causes hypertension in pregnant rats Am J Reprod Immunol. 2024;91:e13805 | 2023 |
Abstracts | |
| Patrícia Braga da Silva; Mariana Romao-Veiga; José Carlos Peraçoli; Maria Terezinha Serrão Peraçoli; AMARAL,LM EFFECT OF PROGESTERONE ON JURKAT CELLS STIMULATED WITH PLASMA OF PREGNANT WOMEN WITH PREECLAMPSIA XXIV FIGO World Congress of Gynecology and Obstetrics | 2023 |
| Nathan Campbell, Luke Strong, Xing Fang, Jane Border, Owen Herrock, Ty Turner, Evangeline Deer, Lorena AMARAL, Richard Roman, Babbette LaMarca AT1-AA Exposure During Pregnancy Impairs Maternal Cerebral Blood Flow Autoregulation Postpartum Physiology.2023, Volume 38, Issue S1. American Physiology Summit 2023 Meeting Abstracts | 2023 |
| Owen Herrock, Kimberly Simmons, Evangeline Deer, Rachael Morris, Richard Roman, Luke Strong, Ty Turner, Nathan Campbell, Lorena AMARAL, Babbette LaMarca Adoptive transfer of CD4+ T cells from women with preeclampsia with or without a history of COVID during pregnancy contribute to hypertension, AT1-AA, and neurovascular dysfunction in pregnant rats. Physiology.2023, Volume 38, Issue S1. American Physiology Summit 2023 Meeting Abstracts | 2023 |
| AMARAL,L; McCray, M; Evans,k; Hines,D; Campbell,N; Deer,E; Herrock,O; Turner, T ; Wallace,K; Ibrahim,T; Lawson,F; Harrell,A; LaMarca, B 17-Hydroxyprogesterone caproate lowers angiotensin II type 1 receptor agonistic autoantibody and improves hypertension in early-onset preeclampsia Physiology, Volume 38, S1 | 2023 |
| Deer, E; Williams, JM; Herrock, O; Campbell, N; Johnson, T; Wilson, M; AMARAL,L, Babbette LaMarca Adoptive transfer of gestational diabetic CD4+T cells cause increased glucose, blood pressure, and placental mitochondrial dysfunction in a novel rat model of diabetes during pregnancy Physiology.2023,Volume 38 Issue S1. American Physiology Summit 2023 Meeting | 2023 |
| Owen Herrock, Kimberly Simmons, Evangeline Deer, Rachael Morris, Richard Roman, Luke Strong, Ty Turner, Nathan Campbell; AMARAL,L; Babbette LaMarca Adoptive transfer of CD4+ T cells from women with preeclampsia with or without a history of COVID during pregnancy contribute to hypertension, AT1-AA, and neurovascular dysfunction in pregnant rats | 2023 |
| Deer, E; Scipio, T; Johnson, J; Williams, JM; Herrock, O; Campbell, N; AMARAL, LM; LaMarca, B Adoptive transfer of diabetic CD4+ T-cells into normal pregnant rats induces characteristics of gestational diabetes AJOG. 2023, VOLUME 228, ISSUE 1, SUPPLEMENT , S637-S638 | 2023 |
| Sullivan, KS; Deer, E; Herrock, O; Morris, R; Roman, R; Strong, L; Turner,TY; Campbell,N; AMARAL, LM; LaMarca, B CD4+ T-Cells cause cognitive dysfunction in preeclampsia or COVID-19 infection in a pregnant rat model Am J Obstet Gynecol. 2023 Jan; 228(1): S675–S676. | 2023 |
| Evangeline M Deer, Jan M Williams, Lorena AMARAL, Sarah Fitzgerald, Owen Herrock, Nathan Campbell and Babbette B Lamarca Gestational Diabetic Cd4+ T Cells Cause Increased Glucose, Blood Pressure And Placental Mitochondrial Dysfunction In A Novel Rat Model Of Diabetes During Pregnancy Hypertension. 2022;79:A014 | 2022 |
| Owen T Herrock, Lorena M AMARAL, Evangeline M Deer, Nathan Campbell, Rachael Morris, Sarah Fitzgerald, Baoying Zheng, Ja'Nasa Hardy-Hardin, Kathy Cockrell and Babbette B Lamarca B Cells Induce Hypertension, AT1AA, And Complement Activation In Preeclampsia Or In Response To A Prior Covid-19 Infection During Pregnancy Hypertension. 2022;79:A018 | 2022 |
| AMARAL,L; McCray,M; Evans,k; Deer,E; Herrock,O; Ingram,N; Wallace,K; Turner,T; Campbell,N; Hogg,J; Solise,D; Reeve,k; LaMarca,B Progesterone prolongs time to delivery and attenuates blood pressure possibly by improving inflammation and endothelial function in response to preeclampsia The Faseb Journal. 2022, Volume 23, Issue S1 | 2022 |
| Herrock,O; AMARAL,L; Deer, E; Campbell; NT; Fitzgerald, ST; Cockrell, K; LaMarca, B The Role of B Cells in Mediating Hypertension in Preeclampsia or COVID‐19 Infection During Pregnancy FASEB J. 2022 May; 36(Suppl 1): 10.1096/fasebj.2022.36.S1.R5913. | 2022 |
| AMARAL;LM; McCray,M ;Evans; E; Lawson, F; Kedra Wallace, K; Ibrahim, T; Hogg, JP; Reeve, k; Solise, D Herrock, O; Campbell, N; Turner, T; LaMarca, B 17-OHPC reduces blood pressure, markers of inflammation and prolongs time to delivery during preeclampsia AJOG.2022 Volume 226, Issue 1, Supplement,S512 | 2022 |
| Nathan Campbell, Owen Herrock, Dylan Solise, Sarah Fitzgerald, Evangeline Deer, Ty Turner, Kathy Cockrell, Tarek Ibrahim, Morgan McCray, Kymberlee Evans, Nicole Ingram, AMARA, LM and Babbette A Lamarca Maternal B Cell Depletion Lowers Blood Pressure And Improves Fetal Weights In Offspring In A Rat Model Of Preeclampsia Hypertension. 2021;78:A19 | 2021 |
| Fitzgerald, SJ; Hogg, J; Deer, E; Campbell, N; Herrock, O; Lemon, J; AMARAL, LM; Cornelius, DC; Cockrell, K; Ibrahim, T; Turner, T; Babbette, L IL-17 Causes Hypertension, Reduced Fetal Weight And Natural Killer Cell Activation In The Absence Of T Cells Hypertension. 2021;78:A26 | 2021 |
| Owen T Herrock, Darby Whitney, Lorena M AMARAL, Nathan Campbell, Nicole Ingram, Ty Turner, Evangeline Deer, Kathy Cockrell, Sarah Fitzgerald and Babbette A Lamarca Inhibiting B Cell Activating Factor Normalizes The Hypertension And Cytolytic Natural Killer Cells Associated With Placental Ischemia | 2021 |
| AMARAL,L; Cottrell,J; Witcher,A; Comley,K; Cornelius,D; Cunningham Jr.,M; Ibrahim,T;LaMarca,B Progesterone and PIBF: new insights into treatment options for preeclampsia | 2021 |
| Reeve, K; Amaral, L; Fitzgerald, S; Ibrahim, T; Deer, Evangeline; Herrock, O; Harmon; A; Wallukat, G; Dechend, R; LaMarca, B Preeclamptic placental CD4+T cells cause hypertension, AT1-AA stimulation and cNK cells in pregnant nude-athymic rats VOLUME 224, ISSUE 2, SUPPLEMENT , S321. | 2021 |
| Lorena M AMARAL, Alexis Witcher, Kyleigh Comley, Tarek Ibrahim and Babbette B Lamarca Progesterone Induced Blocking Factor Blockade Increases Inflammation And Markers Of Endothelial Dysfunction In Pregnant Rats Hypertension. 2020;76:AP210 | 2020 |
| Olivia K Travis, Cedar Baik, Geilda A Tardo, AMARAL,LM Carmilya Jackson, Mallory Greer, Chelsea Giachelli, Jan M Williams and Denise C Cornelius Placental Ischemia-Stimulated Natural Killer Cells Contribute To Hypertension, Vascular Dysfunction, And Intrauterine Growth Restriction In Pregnant Rats Hypertension. 2020;76:AP213 | 2020 |
| Deer, E; Comley,K Denise C Cornelius, Jalisa Jones, Tarek Ibrahim, Ramana Vaka, Michael Franks, AMARAL, LM Progesterone Induced Blocking Factor Decreases Hypertension, Mitochondrial Dysfunction And Reactive Oxygen Species In Response To Elevated Sflt-1 During Pregnancy Hypertension. 2020;76:AP222 | 2020 |
| Inhibiting Progesterone induced blocking factor induces markers of endothelial dysfunction and inflammation in pregnant rats Amaral,LM; Witcher, A; Comley,K; Cottrell,J; Mark W. Cunningham Jr.,MW; Ibrahim, T | 2020 |
| WitcheR, A; Comley, k; Cottrell,J; Cunningham Jr., M; Ibrahim,T; LaMarca,B; Amaral, LM Progesterone induced blocking factor inhibition causes inflammation and endothelial dysfunction in pregnant Sprague Dawley rats | 2020 |
| AMARAL, LM; Cunningham Jr.,MW; Vaka,VK; Ibrahim,T; LaMarca, B Progesterone Supplementation Abolishes Sflt-1 Induced Hypertension In Pregnant Rats Hypertension. 2018;72:AP315 | 2018 |
| AMARAL,LM; Cunningham Jr, MW; Cottrell, J; Cornelius, DC; Ibrahim,; LaMarca, B Progesterone Induced Blocking Factor Improves Clinical Characteristics of Preeclampsia in Rupp Rats Hypertension. 2018;72:A137 | 2018 |
| Lorena M Amaral, Denise Cornelius, Kedra Wallace, Luissa Kipprono, Janae Moseley, Florian Herse, Gerd Wallukat, James N Martin, Ralf Dechend and Babbette LaMarca Progesterone Supplementation Attenuates Hypertension And AT1-AA in Response Tt Elevated IL-6 During Pregnancy Hypertension. 2013;62:A542 | 2018 |
| Amaral,LM; Palei,AC; Pinheiro,LC; Sertorio, JT Guimaraes,DA; Portela, RL;Tanus-Santos;JE Effects of Inhibiting of Inducible Nitric Oxide Synthase in the Pathophysiology of Experimental Preeclampsia | 2018 |
| AMARAL,LM; Cottrell, J; Harmon,A; Cornelius,DC; CunninghamJr,M W; Wallukat,G; Herse,F; Ibrahim,T; Ralf Dechend, R; laMarca, B Interleukin-4 Supplementation Improves Chronic Inflammation and Hypertension in Response to Placental Ischemia During Pregnancy Hypertension. 2017;70:AP271 | 2017 |
| AMARAL,LM; Elfarra,J; Cornelius, DC; CunninghamJr,MW Ibrahim,T; LaMarca,B 17-hydroxyprogesterone Caproate Improves Blood Pressures and Placental Cytolytic Nk Cells in Response to Placental Ischemia During Pregnancy Hypertension. 2016;68:AP174 | 2016 |
| AMARAL,LM; Elfarra,J; Cornelius,DC; Faulkner,JL; CunninghamJr., MW; Mcafee,TR; D’Andrea S Thomas, LaMarca,B Early Administration of 17-hydroxyprogesterone Caproate Improves Fetal Growth Restriction Possibly by Reducing Sflt-1 and Placental Cytolytic Nk Cells in Response to Placental Ischemia During Pregnancy | 2015 |
| Santiago-Font,J; AMARAL, LM; Gillis,E; Moseley,J; LaMarca,B; Sasser,J Serelaxin reduces mean arterial pressure (MAP) and improves fetal growth in the RUPP rat model of preeclampsia American Journal of Obstetrics and Gynecology.35th Annual Meeting of the Society for Maternal-Fetal Medicine. 2015, Volume 212, Issue 1, Supplement, Pages A1-A44, S1-S456 | 2015 |
| AMARAL,LM; Cornelius, DC; Harmon, A; Moseley, J; James Martin, JM; LaMarca,B 17-Hydroxyprogesterone Caproate Significantly Improves Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model Hypertension. 2015;65:225–231 | 2014 |
Thesis | |
| AMARAL, Lorena Machado Effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia Thesis (Doctorate in Pharmacology) - Faculdade de Medicina de Ribeirão Preto, University of São Paulo, Ribeirão Preto, 2012. | 2012 |
Book | |
| Edited by Warrington JP, Palei AC, Cunningham MK, AMARAL LM. The pathophysiology of preeclampsia Cells, January 2023, Pages: 334 | 2023 |
Presentations
| Forum, EmpowerUS Gulf South Women’s Health Forum, Tulane University and and LSUHSC-New Orleans, New Orleans | 12/2024 |
| National and International Invited Seminars/Lectures, Progesterone as a treatment option for Preeclampsia, ZOOMing In On Preeclampsia Research Seminar Series, Virtual | 10/2024 |
| Poster Presentation, Progesterone supplementation reduces symptoms of Preeclampsia in response to preeclamptic placental CD4+ T cells in pregnant nude-athymic rats, The American Society for Reproductive Immunology, Houston, Tx | 05/2024 |
| Poster Presentation, Progesterone supplementation improves the maternal syndrome of superimposed preeclampsia in the Dahl Salt Sensitive Rats, American Physiology Summit, Long Beach, CA | 04/2024 |
| Poster Presentation, Progesterone supplementation reduces AT1-AA and maternal blood pressure in response to preeclamptic placental CD4+ T cells in pregnant nude-athymic rats, Society for Reproductive Investigation, Vancouver, Canada | 03/2024 |
| Regional Invited Seminars/Lectures, Progesterone as a potential treatment for preeclampsia, Texas A&M University School of Medicine, College Station, Tx | 02/2024 |
| Regional Invited Seminars/Lectures, Progesterone as a treatment option for Superimposed Preeclampsia, MS CEPR NIGMS External Advisory Committee Meeting, UMMC | 01/2024 |
| State/Local Invited Seminars/Lectures, Connect, Share, Advance (CSA) session- Career Path, Group on Women in Medicine and Science Office of Diversity and Inclusion, Jackson, MS | 09/2023 |
| National and International Invited Seminars/Lectures, Research interest and academic trajectory, Global July 2023, Juiz de Fora, Brazil | 07/2023 |
| Regional Invited Seminars/Lectures, Progesterone as a treatment option for Superimposed Preeclampsia, Jackson, MS, MS CEPR NIGMS External Advisory Committee Meeting | 01/2023 |
| National and International Invited Seminars/Lectures, Brain, preeclampsia and Therapeutics, 23rd World Congress of the International Society for the Study of Hypertension in Pregnancy, Montpellier, France | 08/2022 |
| National and International Invited Seminars/Lectures, Progesterone reduces inflammation, markers of endothelial dysfunction and maternal blood pressure in response to preeclampsia, 23rd World Congress of the International Society for the Study of Hypertension in Pregnancy, Montpellier, France | 08/2022 |
| Invited Symposia, Short Oral Presentation Session 8: Medically Assisted Procreation and HDP, 23rd World Congress of the International Society for the Study of Hypertension in Pregnancy, Montpellier, France | 08/2022 |
| Workshop, Panel discussion on “2021 Leadership Development Program (LDP) Participant Perspectives", 2nd Leadership Development Conference, Group on Women in Medicine and Science, University of Mississippi Medical Center, University of Mississippi Medical Center | 04/2022 |
| Poster Presentation, Progesterone prolongs time to delivery and attenuates blood pressure possibly by improving inflammation and endothelial function in response to preeclampsia, Experimental Biology, Philadelphia, Pennsylvania | 04/2022 |
| Poster Presentation, 17-orthohydroxyprogesterone caproate prolongs time to delivery and lowers blood pressure in patients with preeclampsia possibly by improving endothelial function, Society for Reproductive Investigation’s 69th Annual Scientific Meeting., Denver, CO | 03/2022 |
| Poster Presentation, 17-OHPC reduces blood pressure, markers of inflammation and prolongs time to delivery during preeclampsia, 42nd Annual Pregnancy Meeting™- SMFM, Orlando, FL | 02/2022 |
| Regional Invited Seminars/Lectures, Progesterone and PIBF: new insights into treatment options for preeclampsia, HSC- Physiology and Anatomy Seminar Series 2022, Forth Worth, Texas | 01/2022 |
| State/Local Invited Seminars/Lectures, 2021-2022 Group on Women in Medicine and Science (GWIMS) Research Interest Group: Virtual Session on Career Opportunities for Women in Medicine and Science, Group on Women in Medicine and Science (GWIMS), Jackson, MS | 10/2021 |
| State/Local Invited Seminars/Lectures, Career Development Award (CDA), Grant Workshop for UMMC Postdocs , Graduate School, Jackson, MS | 08/2021 |
| Regional Invited Seminars/Lectures, Progesterone and PIBF: new insights into treatment options for preeclampsia, Mississippi Center for Clinical and Translation Research (MCCTR) Annual Retreat and External Advisory Committee Meeting, Jackson, MS [virtual] | 05/2021 |
| Poster Presentation, Progesterone Induced Blocking Factor Blockade Increases Inflammation And Markers Of Endothelial Dysfunction In Pregnant Rats, AHA Council on Hypertension Scientific Sessions, Virtual | 09/2020 |
| Poster Presentation, Inhibiting Progesterone induced blocking factor induces markers of endothelial dysfunction and inflammation in pregnant rats, Experimental Biology, San Diego, CA | 04/2020 |
| National and International Invited Seminars/Lectures, Progesterone induced blocking factor attenuates hypertension, placental and endothelial cell mitochondrial dysfunction and reactive oxygen species in response to sFlt-1 during pregnancy, Society for Reproductive Investigation, Vancouver, Canada | 03/2020 |
| National and International Invited Seminars/Lectures, Inhibition of progesterone induced blocking factor increases inflammation and markers of endothelial dysfunction in pregnant Sprague Dawley rats, 40th Annual Pregnancy Meeting- SMFM, Grapevine, Texas | 02/2020 |
| AHA Research Leaders Academy, AHA Research Leaders Academy, American Heart Association, Baltimore, MD | 09/2019 |
| National and International Invited Seminars/Lectures, Inhibition of Progesterone induced blocking factor causes clinical characteristics of preeclampsia in Sprague Dawley rats, High Blood Pressure Council (HBPR) Scientific Sessions, New Orleans, LA | 09/2019 |
| Poster Presentation, Interleukin-4 supplementation improves the proinflammatory cell ratios, autoantibodies and blood pressure in response to placental ischemia, Experimental Biology, Orlando, FL | 04/2019 |
| Poster Presentation, Progesterone Induced Blocking Factor Improves the Pathophysiology of Preeclampsia in Response to Placental Ischemia during Pregnancy, Society for Reproductive Investigation’s 66th Annual Scientific Meeting., Paris, France | 03/2019 |
| State/Local Invited Seminars/Lectures, Anti-inflammatory effects of progesterone: missing in action during preeclampsia, MS CEPR NIGMS External Advisory Committee Meeting | 01/2019 |
| National and International Invited Seminars/Lectures, Progesterone induced blocking factor improves clinical characteristics of preeclampsia in Rupp rats, High Blood Pressure Council (HBPR) Scientific Sessions, Chicago, IL | 09/2018 |
| Poster Presentation, Progesterone supplementation abolishes sFlt-1 induced hypertension in pregnant rats, High Blood Pressure Council (HBPR) Scientific Sessions, Chicago, IL | 09/2018 |
| Poster Presentation, Interleukin-4 Supplementation Improves Chronic Inflammation and Hypertension in Response to Placental Ischemia During Pregnancy, AHA Council on Hypertension, San Francisco, CA | 09/2017 |
| Poster Presentation, 17-Hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing inflammation and placental cytolytic NK cells in response to placental ischemia during pregnancy, Experimental Biology 2017, Chicago, IL | 04/2017 |
| National and International Invited Seminars/Lectures, Administration of 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFlt-1 and placental cytolytic NK cells in response to placental ischemia during pregnancy, 20th World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP), Sao Paulo, Brazil | 10/2016 |
| Invited Symposia, Concurrent Oral Sessions: Pathophysiology of Pre-eclampsia, 20th World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP), Sao Paulo, Brazil | 10/2016 |
| Poster Presentation, 17-hydroxyprogesterone caproate improves blood pressures and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council on Hypertension Sciences 2016 Scientific Sessions, Orlando, FL | 09/2016 |
| National and International Invited Seminars/Lectures, Early administration of 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFlt-1 and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council for High Blood Pressure Research, Washington, DC | 09/2015 |
| Poster Presentation, Early Administration of 17-Hydroxyprogesterone Caproate to Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia Improves Inflammation, Uterine artery Vasoconstriction and Blood Pressure During Pregnancy, Experimental Biology 2015, Boston, Ma | 05/2015 |
| Poster Presentation, Serelaxin Improves Blood Pressure and Uterine Artery Resistance in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia, Experimental Biology 2015, Boston, MA | 05/2015 |
| National and International Invited Seminars/Lectures, 17 Ortho-hydroxyprogesterone caproate improves blood pressure and uterine artery resistance in response to placental ischemia during pregnancy, Council for High Blood Pressure Research, New Orleans | 09/2014 |
| Poster Presentation, Progesterone supplementation improves blood pressure and uterine artery resistance and hypoxia-stimulated placental cytokines during pregnancy, Experimental Biology Meeting, San Diego, CA | 04/2014 |
| Poster Presentation, Progesterone supplementation attenuates hypertension and AT1-AA in response to elevated IL-6 during pregnancy, Council for High Blood Pressure Research, New Orleans, LA | 09/2013 |
| Invited Symposia, Progesterone supplementation attenuates hypertension and AT1-AA in response to elevated IL-6 during pregnancy, 3rd ISH New Investigators’ Symposium on Hypertension and Cardiovascular Disease, New Orleans, LA | 09/2013 |
| Poster Presentation, Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy, Workshop of Atherosclerosis and Vascular Biology - Translating Vision: from laboratory to clinic, Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy | 10/2010 |
| Poster Presentation, Increased circulating cell-free DNA levels in preeclampsia and gestational hypertension, 42º SBFTE Meeting, Ribeirao Preto, SP, Brazil | 10/2010 |
| Poster Presentation, Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental preeclampsia, High Blood Pressure Research Council (HBPR) Scientific Session, Washington, DC |
Honors, Awards, and Recognition
| Fellow of the American Heart Association (FAHA), American Heart Association | 2024 |
| SRI URM Travel Award, Society for Reproductive Investigation | 2024 |
| Research Excellence Award: Bronze Award Level, University of Mississippi Medical Center | 2023 |
| Discovery Awards: Early Career Investigator, University of Mississippi Medical Center | 2023 |
| Early-Career Faculty Award, Group on Women in Medicine and Science, UMMC | 2023 |
| Young Investigator Project Award, MS CEPR - Mississippi Center of Excellence in Perinatal Research | 2022 |
| Esprit De Corps Honorable Mention for GWIMS, The Pillars: Recognition of Service and Inclusive Excellence, UMMC | 2021 |
| Pilot Project Award, Mississippi Center for Clinical and Translational Research, UMMC | 2020 |
| AFHRE Travel Grants for Support of Underrepresented Minorities, Council (HBPR) Scientific Sessions. | 2020 |
| Onsite Poster Competition award at the HTN 2019 Scientific Sessions, Council on Hypertension | 2019 |
| Finalist for the Stephanie Watts Career Development Award, High Blood Pressure Council (HBPR) Scientific Sessions | 2019 |
| Career Development Award, American Heart Association | 2019 |
| Pilot Project Award, MS CEPR - Mississippi Center of Excellence in Perinatal Research | 2018 |
| Postdoctoral Research with Distinction Award, American Physiological Society | 2018 |
| Underrepresented Postdoctoral Scientist Travel Award, American Physiological Society | 2017 |
| APS Minority Travel Fellowship Awards, American Physiological Society | 2017 |
| 20th World Congress of International Society for the Study Hypertension in Pregnancy Travel Award, International Society for the Study Hypertension in Pregnancy | 2016 |
| Pilot Project Project, AMAG Pharmaceuticals | 2016 |
| Annual Hypertension Conference Travel Awards for New Investigators, Council | 2015 |
| WEH/AJP: Regulatory, Integrative, and Comparative Trainee Abstract Award, American Physiological Society | 2015 |
| Caroline tum Suden/Hellebrandt Professional Opportunity Award, American Physiological Society | 2015 |
| International Society for Study of Hypertension in Pregnancy President Award: The Most Outstanding Basic Science Oral Presentation in Relation to the Study of Hypertension in Pregnancy, International Society for the Study Hypertension in Pregnancy | 2014 |
| International Society for Study of Hypertension in Pregnancy New Investigator Travel Award, International Society for the Study Hypertension in Pregnancy | 2014 |
| The American Physiological Society Water and Electrolyte Homeostasis Postdoctoral Research with Distinction Award, American Physiological Society | 2014 |
| Predoctoral fellowship, Fundação de Amparo à Pesquisa de São Paulo’ (FAPESP), Sao Paulo, Brazil | 2011 |
| Master Degree fellowship, Conselho Nacional de Desenvolvimento Científico e Técnológico’ (CNPq), Brazil | 2009 |
Professional Membership and Service
| The American Society for Reproductive Immunology ( ASRI), Member | 2024 - Present |
| Southern Society for Clinical Investigation, Member | 2023 - Present |
| Society for Reproductive Investigation (SRI), Member | 2019 - Present |
| The Society for Maternal-Fetal Medicine ( SMFM), Member | 2018 - Present |
| Group on Women in Medicine and Science (GWIMS), Member | 2016 - Present |
| International Society of Hypertension (ISH), Member | 2014 - Present |
| American Society for Pharmacology and Experimental Therapeutics (ASPET), Member | 2014 - Present |
| International Society for Study of Hypertension in Pregnancy (ISSHP), Member | 2014 - Present |
| American Heart Association (AHA), Member | 2013 - Present |
| American Society of Physiology (APS), Member | 2013 - Present |
| Brazilian Society for Pharmacology and Experimental Therapeutics, Member | 2009 - 2011 |
Committee Service
| Society for Reproductive Investigation (SRI)-365 Committee, Steering Committee Member | 2024 - Present |
| Diversity, Equity and Inclusion Committee- Society for Reproductive Investigation (SRI), Steering Committee Member | 2024 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL, Steering Committee Member | 2024 - Present |
| Master of Science in Clinical Investigation Admission Committee, Steering Committee Member | 2023 - Present |
| M.S. Advisory Committee, Student Dylan Solise, Member | 2022 - 2023 |
| Ph.D. Advisory Committee, Student Nathan Campbell, Member | 2021 - Present |
| SCHOOL OF MEDICINE-CURRICULUM, Steering Committee Member | 2021 - Present |
| MEDICAL CENTER-DIVERSITY, Steering Committee Member | 2021 - 2022 |
| SCHOOL OF MEDICINE-CURRICULUM, Steering Comittee Member | 2021 - Present |
| M.S. Advisory Committee, Student James Hogg, Member | 2021 - 2022 |
| Pharmacology Admission Committee, Steering Committee Member | 2020 - Present |
| Ph.D. Advisory Committee, Student Owen Herrock, Member | 2020 - 2023 |
| MEDICAL CENTER-DIVERSITY, Steering Committee Member | 2020 - 2021 |
| MEDICAL CENTER-DIVERSITY, Member | 2017 - 2018 |
| ASPET mentoring program for Experimental Biology, Mentor | 2017 - 2017 |
| M.S. Advisory Committee, Student Dylan Solise, Member | |
| MEDICAL CENTER-RESEARCH ADVISORY |
Community Service
| APS Mentoring on Go program, Mentor | 04/2021 - Present |
| ASPET mentoring program for Experimental Biology, Mentor | 04/2017 - 04/2017 |
| Bruce Award judges for Experimental Biology 2017, Judge | 04/2017 - 04/2017 |
| Science Fair Judge for Local and District High School Science Fairs, Judge | 07/2014 - 07/2014 |
| American Physiological Society’s Physiology Understand (PhUn) Week Outreach, Participant | 04/2013 - 04/2014 |
Other Service
| Judge for the SGSHS Research Day poster presentations | 10/2024 - 10/2024 |
| Society for Maternal Fetal Medicine:Annual meeting Abstract Reviewer, Abstract Reviewer | 05/2024 - Present |
| Judge for the 2024 SHRP Research | 04/2024 - 04/2024 |
| COBRE Pilot Grants Review Committee | 04/2024 - Present |
| 2024 SRI Mentor-in-a-Cloud, Mentor | 03/2024 - Present |
| Poster Judge for the 2023 SGSHS Research Day | 10/2023 - 10/2023 |
| Judge for the SGSHS Research Day poster presentations | 11/2022 - 11/2022 |
| AHA Fellowship Immunology Peer Review Committee | 08/2022 - Present |
| Group on Women in Medicine and Science (GWIMS), Award Review | 07/2022 - 07/2022 |
| Journal of Inflammation Research | 05/2022 - Present |
| American Heart Fellowship Clinical Peer Review Committee | 08/2021 - Present |
| Society for Reproductive Investigation:Annual meeting Abstract Reviewer, Abstract Reviewer | 07/2021 - Present |
| Judge for Research Day, School of Health Related Professions Research Day | 03/2021 - Present |
| Cells Journal, Guest Editor | 01/2021 - 2023 |
| Connect, Share and Advance Monthly Sessions, Group on Women in Medicine and Science (GWIMS) | 07/2020 - 06/2021 |
| PLOS One | 02/2019 - Present |
| Biology of Sex Differences | 11/2018 - Present |
| BMC Pregnancy and Childbirth | 09/2018 - Present |
| Cells | 07/2018 - Present |
| American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 07/2018 - Present |
| Hypertension | 07/2018 - Present |
| Heliyon | 05/2018 - Present |
| Circulation | 08/2017 - Present |
| Lipids | 07/2017 - Present |
Teaching Experience
| Medicine, Course, Mentor, Preclinical Advising Program: SOM Foundational Sciences Subcommittee Initiative | Annual 2024-2025 |
| PHARM 798-6, Graduate, Course, Course Director, Dissertation and Dissertation Research | Annual 2024 |
| PH701-1, Graduate, Course, Course Director, Pharmacology Seminar | Annual 2024 |
| MSCI 791-5, Graduate, Course, Course Director, Capstone Project Section 5 | Annual 2024 |
| MSCI 791-4, Graduate, Course, Course Director, Capstone Project Section 4 | Annual 2024 |
| MSCI 791-2, Graduate, Course, Course Director, Capstone Project Section 2 | Annual 2024 |
| MSCI 740-1, Graduate, Course, Course Director, Applications of Drugs and Devices in Clinical Research | Fall 2024 |
| PH723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Fall 2024 |
| Medicine, Course, Mentor, Preclinical Advising Program: SOM Foundational Sciences Subcommittee Initiative | Annual 2023-2024 |
| Pharm 792, Graduate, Lab, Lab Director, Research in Pharmacology and Toxicology. | Spring 2023-2024 |
| PH701-1, Graduate, Course, Course Director, Pharmacology Seminar | Annual 2023 |
| PH726, Dentistry, Course, Lecturer, Fundamentals of Pharmacology | Spring 2023 |
| PH723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Fall 2023 |
| MSCI 791-02, Graduate, Course, Course Director, Capstone Project Section 2 | Annual 2023 |
| MSCI 791-04, Graduate, Course, Course Director, Capstone Project Section 4 | Annual 2023 |
| MSCI 791-05, Graduate, Course, Course Director, Capstone Project Section 5 | Annual 2023 |
| PHARM 798-2, Graduate, Course, Lecturer, Dissertation and Dissertation Research | Annual 2023 |
| Medicine, Small Group, Preclinical Advisor, Small Group evaluations and the Preclinical Advising Program | Spring 2023 |
| PH726, Medicine, Course, Lecturer, Medical Pharmacology | Spring 2022 |
| PH726, Dentistry, Course, Lecturer, Fundamentals of Pharmacology | Spring 2022 |
| PH701-1, Graduate, Course, Course Director, Pharmacology Seminar | Annual 2022 |
| Graduate, Course, Lecturer, Didactics- Maternal Fetal Medicine | Annual 2021 |
| PH723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Fall 2020 |
| NSCI 708, Graduate, Lecture, Facilitator, Special Topics in Neuroscience | Summer 2020 - 2020 |
| PH702, Graduate, Course, Course Director, Recent Advances in Pharmacology and Toxicology | Annual 2020 - 2022 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2019 |
| PH702, Graduate, Course, Facilitator, Recent Advances in Pharmacology and Toxicology | Annual 2019 - 2020 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2017 - 2017 |
| Medicine, Course, Lecturer, Research Tools Molecular Biology MFM Fellows | Annual 2014 - 2014 |
| Medicine, Small Group, Facilitator, Medical Pharmacology course | Fall 2014 - 2015 |
Directed Student Learning
| Supervised Research, Advised: Jada Hall | 2024 - Present |
| Supervised Research, Advised: John Price | 2024 - 2024 |
| Supervised Research, Advised: Richard Rein | 2024 - 2024 |
| Supervised Research, Advised: Destyn Jones | 2024 - 2024 |
| Supervised Research, Advised: Raegyn Phillips | 2023 - 2024 |
| Dissertation Committee Chair, Advised: Christy Chambers | 2023 - Present |
| Supervised Research, Advised: Michael Franks | 2023 - 2023 |
| Dissertation Committee Member, GDF15: Anotação funcional de SNPs não codificantes, validação funcional de sequência candidata a acentuadora, e estudo do seu potencial papel como biomarcador da Pré-eclâmpsia Advised: Daniela Alves | 2022 - 2024 |
| Supervised Research, Advised: Ariel Jordan | 2022 - 2023 |
| Master's Thesis Committee Member, Profile of TNF - α receptors expressed in CD4+ Th17 lymphocytes in the peripheral blood of pregnant women with preeclampsia Advised: Patricia Da Silva | 2022 - 2023 |
| Supervised Research, Advised: Kyleigh Hankton | 2022 - 2022 |
| Supervised Research, Advised: Dorianne Hines | 2022 - 2023 |
| Dissertation Committee Member, The Role of AT1-AA in Causing Adult Hypertension in Offspring Born with Fetal Growth Restriction Advised: Nathan Campbell | 2021 - 2023 |
| Master's Thesis Committee Member, Specific Inhibitors of TNF-α and AT1-AA Do Not Worsen Offspring Growth, Survival, Cardiovascular Function, or Immunologic Function Advised: Dylan Solise | 2021 - 2023 |
| Supervised Research, Advised: Kymberlee Evans | 2021 - 2021 |
| Supervised Research, Advised: Morgan McCray | 2021 - 2021 |
| Master's Thesis Committee Member, The Role of Activated T cells in Mediating Mitochondrial Dysfunction in IL-17 Induced Hypertension During Pregnancy Advised: James Hogg | 2021 - 2022 |
| Doctoral Advisory Committee Member, The Role of B Lymphocytes in the Pathophysiology of hypertension in response to Placental Ischemia Advised: Owen Herrock | 2020 - 2023 |
| Supervised Research, Advised: Ty Turner | 2020 - 2022 |
| Supervised Research, Advised: Kyleigh Comley | 2020 - 2021 |
| Supervised Research, Advised: Francis Lawson | 2020 - 2020 |
| Supervised Research, The Role of TH17 cells and IL-17 in causing Mitochondrial Dysfunction in Response to Placental Ischemia and its Impact on the IUGR Offspring Advised: Sarah Fitzgerald | 2019 - 2023 |
| Supervised Research, Advised: Jalisa Jones | 2019 - 2019 |
| Supervised Research, Advised: Alexis Meadors | 2018 - 2022 |
| Supervised Research, Advised: Tarek Ibrahim | 2014 - 2015 |
| Supervised Research, Advised: Jessica Faulkner | 2014 - 2015 |
| Supervised Research, Immune Suppression and AT1-AA Blockade: Novel Treatments for Preeclampsia Advised: Ashlyn Harmon | 2013 - 2015 |
| Supervised Research, Advised: Jackeline Machado | 2009 - 2012 |
Fellows supervised
| Clinical Investigation Graduate Program, Research Advisor, 1 fellows supervised | 07/2023 - Present |
| Postdoctoral Fellowship, Supervised Research, 1 fellows supervised | 06/2016 - 05/2021 |
| MFM Fellowship Program, Supervised Research, 8 fellows supervised | 07/2013 - 07/2022 |