Faculty Profiles

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Harry Pantazopoulos, PhD

Harry PantazopoulosAssistant Professor
Office: TRC, Room 407
(6010 815-7983
Email

Research interests

The research of the Pantazopoulos lab is focused on identifying the neuropathological correlates of circadian rhythm and sleep dysfunction in major psychoses, which we pursue using a combination of human postmortem and animal model approaches. Our long-term research goal is to develop a foundation of changes in neurocircuitry regulating circadian rhythm abnormalities associated with mood disturbances in several diseases including bipolar disorder and schizophrenia that we can leverage to develop more effective treatments. In addition, we aim to identify basic biological mechanisms that will provide insight into how clock genes regulate neural functions in a brain region specific manner, linked to specific behaviors.

Additional lab projects consist of extracellular matrix abnormalities in schizophrenia, as well as studies focused on sleep designed to elucidate the role of extracellular matrix molecules, including perineuronal nets, in sleep and memory consolidation.

Current funding

NIH R01 Grant: MH125833
Diurnal Molecular Rhythms of the Human Hypothalamus and Involvement in Bipolar Disorder
2021-2025
Role: PI

Department of Defense Grant: W81XWH-20-1-0772
Matrix metalloproteinases in the degeneration of cochlear synapses
Role: Co-Investigator

Baszucki Brain Research Fund: CACNA1C Genotype: Correlation with Brain and Blood Levels of CACNA1C and Treatment Responsiveness
PI: Harry Pantazopoulos
2021-2022
Role: PI

Recent publications

* In the last four years