Dr. Simino completed formal training in biochemistry, molecular pathology, statistics, chronic disease epidemiology, and genetic epidemiology. Her postdoctoral research focused on the genetic and environmental architecture of cardiovascular traits, particularly blood pressure and lipid levels. Currently, Dr. Simino is investigating the genetic underpinnings of biomarkers of Alzheimer’s Disease and cognitive aging using data from the Atherosclerosis Risk in Communities (ARIC) Study. She has conducted linkage, genome-wide association, and whole exome sequence analyses, as well as meta-analyses of genetic studies from around the world. Her long-term goal is to identify genes that can be therapeutically targeted to improve a patient’s physical and mental health.
Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans: the Atherosclerosis Risk in Communities-Neurocognitive Study. PLoS One (in press). PMID: 280704393
Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, et al. Gene-age interactions in blood pressure regulation: A large-scale investigation using the CHARGE, Global BPgen, and ICBP consortia. Am J Hum Genet. 2014 Jul 3;95(1):24-38. doi: 10.1016/j.ajhg.2014.05.010. Epub 2014 Jun 19. PMID: 24954895