William "Drew" A. Pruett

William "Drew" A. Pruett

Instructor

Department:
SOM-Physiology & Biophysics

Email:
wpruett@umc.edu

Work Phone:
(601) 815-1316

Biography

Dr. Pruett uses computational techniques to study physiological dynamics, especially concerning chronic control of salt/water homeostasis and the impact of the kidney on maladaptive cardiac hypertrophy. In addition to physiological modeling techniques, Dr. Pruett uses machine learning and statistics to create virtual populations and digital twins of individuals in order to study the effect of physiological variation on response to drug and device interventions.

Education

Baylor University, PhD, Mathematics2010

Academic Appointments or Other Previous Appointments

School of Medicine, Department of Physiology And Biophysics06/2013 - 06/2013

Publications

Published Erratum

Clemmer JS, Pruett WA, Lirette ST, Corrigendum: Racial and Sex Differences in the Response to First-Line Antihypertensive Therapy. Frontiers in cardiovascular medicine, 2020;7:643289

Journal Article

Clemmer JS, Pruett WA, Modeling the physiological roles of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy. American journal of physiology. Heart and circulatory physiology, 2022 Sep 1;323(3):H597-H6072022
Speed JS, Pruett WA, Lirette ST, Cook JJ, Phillips CL, Grayson BE, Cardiovascular Risk Factors Following Vertical Sleeve Gastrectomy in Black Americans Compared with White Americans. Obesity surgery, 2021 Mar;31(3):1004-10122021
Pruett WA, Clemmer JS, Hester RL, Physiological Modeling and Simulation-Validation, Credibility, and Application. Annual review of biomedical engineering, 2020 Jun 4;22:185-2062020
Clemmer JS, Pruett WA, Hester RL, Lohmeier TE, Preeminent role of the cardiorenal axis in the antihypertensive response to an arteriovenous fistula: an in silico analysis. American journal of physiology. Heart and circulatory physiology, 2019 Nov 1;317(5):H1002-H10122019
Hester RL, Pruett W, Clemmer J, Ruckdeschel A, Simulation of integrative physiology for medical education. Morphologie : bulletin de l'Association des anatomistes, 2019 Dec;103(343):187-1932019
Clemmer JS, Pruett WA, Hester RL, Iliescu R, Lohmeier TE, Role of the heart in blood pressure lowering during chronic baroreflex activation: insight from an in silico analysis. American journal of physiology. Heart and circulatory physiology, 2018 Nov 1;315(5):H1368-H13822018
Clemmer JS, Hester RL, Pruett WA, Simulating a virtual population's sensitivity to salt and uninephrectomy. Interface focus, 2018 Feb 6;8(1):201601342018
Sims CR 3rd, Delima LR, Calimaran A, Hester R, Pruett WA, Validating the Physiologic Model HumMod as a Substitute for Clinical Trials Involving Acute Normovolemic Hemodilution. Anesthesia and analgesia, 2018 Jan;126(1):93-1012018
Blair ET, Clemmer JS, Harkey HL, Hester RL, Pruett WA, Physiologic Mechanisms of Water and Electrolyte Disturbances After Transsphenoidal Pituitary Surgery. World neurosurgery, 2017 Nov;107:429-4362017
Clemmer JS, Pruett WA, Coleman TG, Hall JE, Hester RL, Mechanisms of blood pressure salt sensitivity: new insights from mathematical modeling. American journal of physiology. Regulatory, integrative and comparative physiology, 2017 Apr 1;312(4):R451-R4662017
Lohmeier TE, Pruett WA, Illogical Critiques of the Pressure Natriuresis Theory of Chronic Hypertension. American journal of hypertension, 2016 Dec 1;29(12):1332-13342016
Pruett WA, Clemmer JS, Hester RL, Validation of an integrative mathematical model of dehydration and rehydration in virtual humans. Physiological reports, 2016 Nov;4(22)2016
Hester RL, Pruett WA, Use of Computer Simulations to Understand Female Physiology: Where's the Data? Physiology (Bethesda, Md.), 2015 Nov;30(6):404-52015
Pruett WA, Hester RL, Parathyroid hormone secretion by multiple distinct cell populations, a time dynamic mathematical model. Physiological reports, 2014 Feb 1;2(2):e002312014
Pruett WA, Hester RL, Coleman TG, The apparent hysteresis in hormone-agonist relationships. Journal of theoretical biology, 2012 Mar 7;296:1-52012
Pruett WA, Hester RL A decision support system predicting imminent cardiovascular shock Proceedings of the Interagency/Industry Training, Simulation, and Education Conference 2014.
Wu K, Chen J, Pruett WA, Hester RL HumMod Browser: An Exploratory Visualization Tool for the Analysis of Whole-Body Physiology Simulation Data IEEE Symposium on Biological Data Visualization. October, 2013
Walters K, Burgreen GW, Hester RL, Thompson D, Lavalee D, Pruett WA, Ford-Green J. Cyclic breathing simulations in large scale models of the lung airway from the oronasal opening to the terminal bronchioles Proceedings of the ASME International Mechanical Engineering Congress and Exposition (2012)
Walters K, Burgreen GW, Hester RL, Thompson D, Lavallee D, Pruett WA, Ford-Green J. Simulations of cyclic breathing in the conducting zone of the human lung. Proceedings of the ASME Fluids Engineering Division Summer Meeting (2012)
Clemmer JS, Pruett WA, Hester RL, In silico trial of baroreflex activation therapy for the treatment of obesity-induced hypertension. PloS one, 2021;16(11):e0259917
Clemmer JS, Pruett WA, Lirette ST, Racial and Sex Differences in the Response to First-Line Antihypertensive Therapy. Frontiers in cardiovascular medicine, 2020;7:608037
Pruett WA, Hester RL, The Creation of Surrogate Models for Fast Estimation of Complex Model Outcomes. PloS one, 2016;11(6):e0156574
Hester RL, Brown AJ, Husband L, Iliescu R, Pruett D, Summers R, Coleman TG, HumMod: A Modeling Environment for the Simulation of Integrative Human Physiology. Frontiers in physiology, 2011;2:12
Pruett WA, Husband LD, Husband G, Dakhlalla M, Bellamy K, Coleman TG, Hester RL, A population model of integrative cardiovascular physiology. PloS one, 2013;8(9):e74329

Book Chapter

Enright TJ, Hunziker M, Pruett WA Diagrams of Hermitian type, highest weight modules, and syzygies of determinental varieties in Symmmetry: Representation Theory and its Applications. Birkhauser, New York 2014

Presentations

Regional Invited Seminars/Lectures, WNK kinases and integration of distal nephron electrolyte reabsorption, SBEC, New Orleans, LA09/2023
State/Local Invited Seminars/Lectures, WNK kinase signaling in the distal nephron, UMMC Physiology Department, Jackson MS04/2023
State/Local Invited Seminars/Lectures, Phenotyping with nearest neighbor error, UMMC, Jackson MS04/2022
State/Local Invited Seminars/Lectures, Models of diastolic heart failure and left ventricular hypertrophy in HumMod, UMMC Department of Physiology, Jackson MS03/2021
State/Local Invited Seminars/Lectures, Predicting nonresponse to renal denervation: an M&S approach, FDA, White Oak MD11/2019
National and International Invited Seminars/Lectures, Digital Twins in Healthcare: an overview, FDA, Silver Spring MD03/2019
National and International Invited Seminars/Lectures, Insights into mechanisms of resistance to renal denervation using topological analysis of simulatio, VPH Society, Zaragoza Esp09/2018
National and International Invited Seminars/Lectures, Understanding and predicting physiological resistance with simulation and topological analysis, Institute for Advanced Mathematics, Minneapolis MN03/2018
National and International Invited Seminars/Lectures, Predicting response to antihypertensive therapy in a broad population with physiological simulation, SSIH, Los Angeles CA01/2018
National and International Invited Seminars/Lectures, The method of relational correlations to determine subpopulation characteristics, FDA, Silver Springs MD05/2017
National and International Invited Seminars/Lectures, Integrative Physiological Modeling: Looking at a larger picture, ICM, State College PA08/2016
National and International Invited Seminars/Lectures, Predicting non-response to renal denervation: an M&S approach, FDA/BMES, Silver Spring MD05/2015
National and International Invited Seminars/Lectures, A decision support system predicting imminent cardiovascular shock, I/ITSEC, Orlando FL12/2014
National and International Invited Seminars/Lectures, Predictive enrichment by systematic integration of multilevel computation with experimental results, MDIC/FDA, Washington DC03/2014
Regional Invited Seminars/Lectures, Generalized Young diagrams for Hermitian symmetric spaces, AMS, Raleigh NC04/2009
National and International Invited Seminars/Lectures, Quotients of finite and affine Weyl groups by maximal parabolic subgroups and applications, MAA/AMS, San Diego CA01/2008
National and International Invited Seminars/Lectures, Divisibility properties of class numbers of composite irreducibles in Fq[T], MAA/AMS, Phoenix AZ01/2004

Honors, Awards, and Recognition

Graduate Student Teacher of the Year, Baylor University2009
Ford Teaching Fellowship, Ford Foundation2004
Ford Teaching Fellowship, Ford Foundation2003

Teaching Experience

BDS 765, Population Health, Course, Lecturer, Advanced Machine LearningFall 2018 - 2021
Physio 701, Medicine, Small Group, Facilitator, PhysiologySpring 2013
Physio 701, Medicine, Lab, Lab Presenter, Medical PhysiologySpring 2012
Physio 744, Graduate, Course, Lecturer, Simulation of Physiological MechanismsSpring 2012