Racial Differences in Cardiovascular Function: The Role of Endothelin-1

About this Study

This research study wants to learn more about the regulation of the blood vessels in Black and White healthy young individuals to better understand the factors that may cause cardiovascular diseases later in life. Your participation will consist of three research clinic visits at the Clinical Research and Trials Unit, room WC753, over up to 4 months. In the research clinic, we will perform several research cardiovascular measurements (for example, electrocardiogram, blood pressure, blood flow, etc.) during procedures to test your blood vessel function (i.e., reactive hyperemia, flow-mediated dilation, blood flow responses to rhythmic handgrip exercise). In one of the research visits, you will ingest either a medicine called Bosentan or a Placebo, and vice-versa in the next research visit.

Sponsor Protocol ID:2020V0181
IRB Number:2020V0181
Actively Enrolling
Observational/Not Applicable
April 12, 2021
Eligibility Criteria
Both Male and Female

Inclusion Criteria

·         Be Black (i.e. African American) or White (i.e. Caucasian              American) individual;

·         Be of 18 to 35 years of age;

·         Be born and raised in the United States;

Exclusion Criteria

·         NOT have any disease, and NOT be on prescribed                      medicine treatment;

·         NOT have a history of liver disease;

·         NOT be pregnant, NOT trying to become pregnant, and              NOT breastfeeding women;

·         NOT use hormonal birth control;

·         NOT have smoked or vaped in the last 6 months;

·         NOT have a Body Mass Index greater than 35 kg/m2.

Categories Click category to view its trials.
Heart Health
Participating Locations
University Hospital
Contact Information
Contact Name: Dr. Thales Barbosa
Phone Number: 601-984-1468
Email: tbarbosa@umc.edu
Principal Investigator:Coelho Barbosa, Thales
How to participate in our Clinical Trials